Diagnosis & Disease Information

Intravitreal Methotrexate Under Review for Primary Vitreoretinal Lymphoma

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application (NDA) for ADX-2191 (methotrexate injection) for the treatment of primary vitreoretinal lymphoma, a rare, aggressive retinal cancer. ADX-2191 is a preservative-free, intravitreal formulation of methotrexate designed to be vitreous-compatible. The application is supported by safety data from the phase 3…

Ophthalmology Dx: The Hole Truth

A 22-year-old patient presented with a retinal hole and a shallow retinal detachment. After treatment, the retina detached again. An inferior detachment was also found. Both were repaired, but then both redetacted. Additional surgeries failed. Can you identify the underlying cause shown in Figure 3?

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