Researchers at McMaster University are addressing the crisis in drug resistance with a novel approach to find new antibiotics.
“We have developed technology to find new antibiotics using laboratory conditions that mimic those of infection in the human body,” said Eric Brown, professor in the Department of Biochemistry and Biomedical Sciences.
When mice ate a diet of 25 percent extra sugar – the mouse equivalent of a healthy human diet plus three cans of soda daily – females died at twice the normal rate and males were a quarter less likely to hold territory and reproduce, according to a toxicity test developed at the University of Utah.
Findings Suggest a Potent New Therapeutic Target for Certain Types of Cancer
Scientists have discovered the survival secret to a genetic mutation that stokes leukemia cells, solving an evolutionary riddle and paving the way to a highly targeted therapy for leukemia. In a paper published today in Cell, researchers at NYU Langone Medical Center describe how a mutated protein, called Fbxw7, behaves differently when expressed in cancer cells versus healthy cells. “Fbxw7 is essential for making blood cells, so the big mystery is why a mutation on a gene so important for survival would persist,” says lead author Iannis Aifantis, PhD, chair of pathology at NYU Langone Medical Center and an Early Career Scientist at Howard Hughes Medical Institute. “What we’ve found is that the mutation affects cancerous cells but not healthy cells.”
The world’s first enduring civilization may have arisen in Egypt; some scholars suggest that the fertile Nile Valley had been settled as early as 10,000 BC. But it wasn’t until the advent of the Old Kingdom, about 2600 BC, that modern historians can begin to form real figures from the dim outlines of a past shrouded in mystery and magic.
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PHILADELPHIA — A series of microRNA expression signatures that may help to define progression of the precancerous condition Barrett’s esophagus into esophageal adenocarcinoma was reported recently in Cancer Prevention Research, a journal of the American Association for Cancer Research.
“Once a rare cancer representing only 5 percent of all esophageal cancers in the United States, esophageal adenocarcinoma is the cancer with the fastest-rising incidence — six-fold increase in the past three decades — and currently comprises more than 80 percent of all new esophageal cancer cases in this country,” said Xifeng Wu, M.D., chair of the Department of Epidemiology, Division of Cancer Prevention and Population Sciences at The University of Texas MD Anderson Cancer Center, in Houston. “To reduce the mortality of esophageal adenocarcinoma, the best hope in the near term is to detect it at its early stage, or even better, to prevent the progression of esophageal adenocarcinoma from its premalignant lesion, which is called Barrett’s esophagus.”
As the nation’s health care system continues to evolve, the AMA is dedicated to promoting scientific advancement, working to ensure that enhancements to health care in the United States are physician led, accelerating advancements in medical education, improving health outcomes, and investing in the physician-patient relationship, including promoting health care costs that can be prudently managed.
