FDA Approves Apretude, a Long-Acting Injectable for HIV PrEP
The application is supported by data from the phase 2b/3 HPTN 083 and HPTN 084 trials, which evaluated the efficacy and safety of Apretude for HIV PrEP.
HIV/AIDS
FDA Places Clinical Hold on Islatravir Trials for HIV-1 Infection
The clinical holds were based on observations from trials that showed a decrease in total lymphocyte and CD4+ T-cell counts among patients treated with islatravir.
Effect of Routine Use of Lubricants on Vaginal Cytokine and Microbiota Profiles
Researchers conducted a study that compared vaginal cytokine and microbiota profiles before and after condomless vaginal intercourse between women who use vaginal lubricants vs those who do not.
Risk Factors Associated With Vertical Transmission in Mothers With HIV Infection
Researchers sought to assess whether there is an association between maternal HIV drug resistance and an increased risk for vertical transmission and to describe the dynamics of drug resistance in infants with HIV infection.
Long-Acting Cabotegravir Gets Priority Review for HIV PrEP
The application is supported by data from two phase 2b/3 trials that evaluated the efficacy and safety of long-acting injectable cabotegravir for HIV pre-exposure prophylaxis.
Treatment for Pneumocystis Pneumonia Recalled Due to Temperature Control Issue
The recall was initiated because the product had prolonged exposure to extremely cold weather during shipment.
Cytomegalovirus Seropositivity May Affect Epigenetic Aging in Healthy Older Adults
Investigators conducted a study to determine whether cytomegalovirus affects epigenetic age and immune dysregulation in healthy older adults who are asymptomatic.
RSV and Parainfluenza Increase Hospitalization Risk in HIV-Exposed Infants
As HIV-exposed, uninfected infants have higher rates of morbidity and mortality than HIV-unexposed uninfected infants, a study was conducted to analyze whether particular infections or immune responses contribute to hospitalization.
Fighting the Syndemic: Addressing Opioid Use Disorder and Decreasing HIV Go Hand-in- Hand
Structural concerns, racial and socioeconomic issues, and state- and federal-level policy present challenges when trying to address the intersecting epidemics of opioid use disorder and HIV.
Quadrivalent HPV Vaccine Prevents High-Grade Squamous Intraepithelial Lesions Among HIV-Positive Men
Researchers examined the efficacy and safety of the quadrivalent human papillomavirus vaccine for young men who have sex with men and are living with HIV.
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