Positive Efficacy Findings Prompt Early Stop of Empagliflozin CKD Trial
The EMPA-KIDNEY study enrolled more than 6600 patients with CKD attributable to a wide range of underlying causes.
Diagnosis & Disease Information
More Data Needed to Make Decision on Bardoxolone in Alport Syndrome
The CRL stated that the application for bardoxolone could not be approved in its current form due to a lack of data supporting claims of slowing kidney function loss and reducing kidney failure progression.
SGLT2 Inhibitors Underprescribed for Chronic Kidney Disease
Affordability of SGLT2i may contribute to the low prescription rate in CKD.
Chlorthalidone Safe, Effective for Treating Hypertension in Advanced CKD
In a study of patients with stage 4 chronic kidney disease and poorly controlled blood pressure, chlorthalidone significantly decreased systolic blood pressure compared with placebo.
Urate-Degrading Enzyme Fast Tracked for Hyperuricemia With Gout and CKD
ALLN-346 is an investigational, first-in-class, nonabsorbed, orally-administered enzyme that breaks down urate in the gastrointestinal tract.
The Potential Dangers of Ketogenic Diets in Kidney Disease
A recent review underscores the possible adverse effects of ketogenic diets, including increased risks for heart disease, cancer, diabetes, and kidney stones.
BMI Fluctuations May Predict Poor Outcomes in CKD
High variability in body mass index is associated with an increased risk for death, requiring kidney replacement therapy, myocardial infarction, and stroke, investigators concluded.
Korsuva Approved for Chronic Kidney Disease-Associated Pruritus
The approval was based on data from the pivotal phase 3 KALM-1 and KALM-2 trials, as well as data from an additional 32 clinical studies.
FDA Wants Another Study Before Deciding on Tenapanor Approval
Tenapanor inhibits the sodium/hydrogen exchanger 3 to control serum phosphorus in adults with CKD on dialysis.
Major Cardiovascular Events Linked to Metabolic Acidosis
Cardiovascular events are the leading cause of death among patients with chronic kidney disease, and metabolic acidosis in this population is underdiagnosed.
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