FDA Clears Language Independent Computerized Test to Detect Cognitive Impairment
By using animal images, the test avoids cultural or educational bias and can be used repeatedly with no learning effect.
Alzheimer Disease and Dementia
FDA Assigns PDUFA Date for Donepezil Transdermal System
Adlarity is a once-weekly transdermal formulation of donepezil.
Differential CSF Biomarkers in Autosomal Dominant AD and Down Syndrome
A team of investigators conducted a cross-sectional study to compare CSF biomarker patterns in Down syndrome compared with those of autosomal dominant Alzheimer disease mutation carriers.
Tau Positron Emission Tomography Better Predicts Cognitive Decline Among Patients With Alzheimer Disease
The researchers sought to understand the prognostic value of tau positron emission tomography for predicting cognitive decline across the clinical spectrum of Alzheimer disease.
First Alzheimer Disease Prevention Trial Using Amyloid-Targeting Drugs Gantenerumab or Solanezumab
The researchers conducted a randomized, placebo-controlled, multi-arm trial of gantenerumab or solanezumab in participants with dominantly inherited Alzheimer disease across asymptomatic and symptomatic disease stages.
Clues to Memory Impairment in Cerebral Amyloid Angiopathy
The researchers’ objective was to assess the neuroimaging features of patients with cerebral amyloid angiopathy, or CAA, with and without objective memory impairment using tau PET imaging.
Meningeal Lymphatic Drainage May Help Improve Alzheimer Disease Outcomes
Using transcriptional profiling of mouse meningeal lymphatic endothelial cells, microglia and brain blood endothelial cells, the researchers showed that meningeal lymphatic function is coupled to microglia and brain vascular activation in Alzheimer disease.
Novel, Rare Variants Associated With Alzheimer Disease and Replicated in an Independent Cohort
The study researchers used deep whole-genome sequencing (WGS) to search for novel AD variants in 2247 individuals from 605 multiplex AD families from the National Institute on Mental Health and the National Institute on Aging (NIA) Alzheimer’s Disease Sequencing Project `data sets.
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