Research

Clinical Practice Guidelines Establish Norms of Practice But Must Reduce Risk for Bias

Clinical Practice Guidelines Establish Norms of Practice But Must Reduce Risk for Bias

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Clinical practice guidelines are an important part of medical practice, but scarce funding for updates and the risk for bias have raised challenges.

Ethical Concerns Arise in Clinical Trial Enrollment as Number of Uninsured and Underinsured Americans Skyrockets

Ethical Concerns Arise in Clinical Trial Enrollment as Number of Uninsured and Underinsured Americans Skyrockets

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Until universal access to healthcare is ensured as a human right, researchers must keep important ethical concerns in mind when designing future clinical trials.

Data Age in Clinical Trials Is About 3 Years at Publication

Data Age in Clinical Trials Is About 3 Years at Publication

The median data age in clinical trials in journals with a high impact factor is about 3 years at publication.

Adverse Effects of Marijuana Use in Pregnancy: Current Research Is Questionable at Best

Adverse Effects of Marijuana Use in Pregnancy: Current Research Is Questionable at Best

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Many women are unconvinced of the potential harmful effects of marijuana use in pregnancy due to the lack of available evidence.

Cochrane Data Release and the Case for "Open Science"

Cochrane Data Release and the Case for "Open Science"

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Cochrane's current policies allow only specific individuals with full library access to view and reuse data reports in their entirety.

Authorship by Female Physicians Inequitably Represented in Pediatric Journals

Authorship by Female Physicians Inequitably Represented in Pediatric Journals

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Authorship of perspective-type articles in high-impact pediatric journals showed fewer female physician first authors despite women outnumbering their male colleagues in the pediatric specialty.

Strategies for Increasing Physician-Scientist Recruitment to Research Careers

Strategies for Increasing Physician-Scientist Recruitment to Research Careers

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From 2003 to 2015, funding for the National Institutes of Health declined by 22% due to a nationwide decrease in biomedical research support.

Addressing Modern Difficulties in Supporting Biomedical Research

Addressing Modern Difficulties in Supporting Biomedical Research

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The past 2 decades of biomedical research have seen a substantial increase in "hypercompetition" for funding.

The FDA Has the Authority to Explain Drug Application Rejections or Approvals. They Should Use It.

The FDA Has the Authority to Explain Drug Application Rejections or Approvals. They Should Use It.

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The FDA has the ability within its governing laws to reveal to the public the reasons for its decisions to reject or approve drugs.

Protecting the Privacy of Study Participants in an Era of Ubiquitous GPS Location Tracking

Protecting the Privacy of Study Participants in an Era of Ubiquitous GPS Location Tracking

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With the explosion of big data and its use in human biomedical research comes the possibility of unauthorized parties accessing data and potentially re-identifying de-identified personal information.

Developing a New Set of Standards for Clinical Research Site Accreditation

Developing a New Set of Standards for Clinical Research Site Accreditation

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Can groups with varying viewpoints come together to agree on a set of standards for the accreditation process?

Association Between Industry Payments and Opioid Prescribing

Association Between Industry Payments and Opioid Prescribing

Non-research industry payments to physicians may be associated with increases in opioid prescribing rates.

Government and Industry Lead the Way in Funding USPSTF Systematic Reviews

Government and Industry Lead the Way in Funding USPSTF Systematic Reviews

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Researchers sought to assess the frequency of specific government agencies and organizations in their funding for the review studies.

Standardized Funder Policies Will Improve Transparency, Publication Bias in Clinical Trials

Standardized Funder Policies Will Improve Transparency, Publication Bias in Clinical Trials

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Research findings suggest the need for greater adherence to a standardized set of policies aimed at improving transparency among clinical trial funders.

Healthy Research Volunteers Require a Unique, Specific Compensation Model

Healthy Research Volunteers Require a Unique, Specific Compensation Model

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Volunteers for clinical research are "renting" out their bodies to help discover how the human body reacts to a device, drug, or therapeutic strategy.

Fewer Pediatric Studies Go Unpublished, Reducing Publication Bias

Fewer Pediatric Studies Go Unpublished, Reducing Publication Bias

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Publication bias compromises scientific research and constitutes a threat to evidence-based medicine.

Greater Credibility Needed in Investigations of Scientific Misconduct Reports

Greater Credibility Needed in Investigations of Scientific Misconduct Reports

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There are substantial limitations to depending only on institutional investigations of scientific misconduct.

Female Authors Less Likely to Be Listed as First Author in Clinical, Basic Science Journals

Female Authors Less Likely to Be Listed as First Author in Clinical, Basic Science Journals

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Female researchers still face challenges when publishing research.

For the Greater Good: Examining the Ethical Obligation of Public Participation in Health Research

For the Greater Good: Examining the Ethical Obligation of Public Participation in Health Research

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Although privacy issues are important, public interest in innovation and affordable healthcare may take precedence.

Many Antibiotic Trials Lack Adequate Informed Consent

Many Antibiotic Trials Lack Adequate Informed Consent

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Noninferiority and superiority trials entail different benefit-harm trade-offs that must be conveyed for ethical informed consent.

Is Scientific 'Spin' Being Used to Detract From Statistically Nonsignificant Trial Results?

Is Scientific 'Spin' Being Used to Detract From Statistically Nonsignificant Trial Results?

Spin in biomedical literature, or "science hype", is prevalent, with trails having the highest and greatest variability in the prevalence of spin.

A Physician Provides Insights on the 'Last Gift Study'

A Physician Provides Insights on the 'Last Gift Study'

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Terminally ill people with HIV have few opportunities to participate in research, but some leave a final gift to their community.

Q&A: How To Obtain Informed Consent From Medical Research Participants

Q&A: How To Obtain Informed Consent From Medical Research Participants

Despite being a relatively new concept in the US, informed consent of study participants in medical research is ethically essential.

How Do You Make the Truth Believable Again?

How Do You Make the Truth Believable Again?

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"Forced to choose between recognizing what is known to science and maintaining our group identity, most of us choose the latter."

Scientists Find Genes That May Help Doctors Predict Cancer Treatment Outcomes

Scientists Find Genes That May Help Doctors Predict Cancer Treatment Outcomes

According to a recent study, scientists have discovered 14 genes that may help physicians predict outcomes of cancer treatments.

Link Identified Between Alzheimer's Disease and Fungus

Link Identified Between Alzheimer's Disease and Fungus

Witnessing a loved one succumb to Alzheimers disease (AD) is one of the most difficult experiences a person has to deal with. Signs of the disease appear slowly at first. The affected individual may forget a word or misplace an object, which is something that happens to everyone from time to time. But then it gets more serious.

Public Health England Says Vaping is 95% Less Harmful Than Smoking. Is it True?

Public Health England Says Vaping is 95% Less Harmful Than Smoking. Is it True?

Electronic cigarettes have become a common product in modern-day culture, so much that its almost more common to see people puffing on them than on conventional cigarettes. But is that really a good thing?

Study Shows Promise of Precision Medicine for Most Common Type of Lymphoma

Study Shows Promise of Precision Medicine for Most Common Type of Lymphoma

A clinical trial has shown that patients with a specific molecular subtype of diffuse large B-cell lymphoma (DLBCL) are more likely to respond to the drug ibrutinib (Imbruvica) than patients with another molecular subtype of the disease. The study appeared online July 20, 2015, in Nature Medicine.

Study Finds Autism, ADHD Run High in Children of Chemically Intolerant Mothers

Study Finds Autism, ADHD Run High in Children of Chemically Intolerant Mothers

A new study from The University of Texas Health Science Center at San Antonio found that mothers with chemical intolerances are two to three times more likely than other women to have a child with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD).

Scientists Find Cellular Mechanism for How the Body Regulates Glucose Transport

Scientists Find Cellular Mechanism for How the Body Regulates Glucose Transport

UT Southwestern Medical Center scientists have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases.

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