Oncology

Epcoritamab Granted Priority Review for Relapsed/Refractory Large B-Cell Lymphoma

Epcoritamab is designed to bind to CD3 on T cells and CD20 on B cells, inducing T cell mediated killing of CD20+ cells.

Most Phase 3 Trials of Newly Diagnosed Glioblastoma Show No Improvement in OS

Most recent phase 3 trials of patients with newly diagnosed glioblastoma have shown no significant improvement in overall survival with the experimental treatment.

FDA Approves Additional Dosing Schedule for Rylaze

The MWF dosing option was approved under the Real-Time Oncology Review program based on data from the intramuscular administration part of a phase 2/3 trial.

Up to 10% of Early-Onset Metastatic Colorectal Cancer Cases May Be Driven by Undiagnosed IBD

As many as 10% of early-onset metastatic colorectal cancer cases may be attributable to undiagnosed inflammatory bowel disease, a study suggests.

Consolidative Stem Cell Transplant May Improve Outcomes Among Patients With Peripheral T-Cell Lymphoma

Researchers sought to determine whether patients with PTCL who have a complete response after A+CHP would benefit from SCT.

Current and Emerging BTK Inhibitors for Chronic Lymphocytic Leukemia

Researchers sought to determine the landscape of BTK inhibitors for treating patients with CLL.

Dose-Dense Adjuvant Chemotherapy “Optimal” for High-Risk, Early Breast Cancer

Dose-dense adjuvant chemotherapy improves disease-free survival in high-risk early breast cancer, according to updated results from the GIM2 trial.

Standing Orders for Primary Prophylaxis Colony-Stimulating Factor to Improve Guideline Adherence

Researchers sought to determine if automated standing orders for prophylaxis colony-stimulating factor would improve adherence to clinical guidelines for use according to risk for febrile neutropenia.

Stigma May Be a Barrier to Lung Cancer Advocacy Among Patients

Results of a cross-sectional survey explain why patients with lung cancer may be reluctant to get involved in advocacy.

Exercise, Physical Activity Beneficial Among Patients With Kidney Cancer

In a study of patients who had ever been diagnosed with kidney cancer, those who reported exercise or physical activity in the past 30 days had reduced likelihood of reporting worse physical and mental health.

Standardized Screening Increases Recognition of Distress in Patients With Cancer

A Plan-Do-Study-Act approach was used to validate a tool for measuring distress and clinical depression in patients with cancer.

Zejula Use for Second-Line Maintenance Treatment Restricted

The decision to restrict the indication follows an FDA review of the double-blind, placebo-controlled phase 3 ENGOT-OV16/NOVA trial.

Elahere Granted Accelerated Approval for Platinum-Resistant Ovarian Cancer

The approval was based on data from the SORAYA trial.

Patients, Clinicians Explain How the Pandemic Affected Genitourinary Cancer Care

A focus group sought to explore the effects of the changes in genitourinary cancer care during the COVID-19 pandemic from the perspective of patients and clinicians.

Stereotactic Ablative Body Radiotherapy “Quite Safe” for Treating Oligometastases

Investigators characterized the toxicity of stereotactic body radiotherapy for oligometastases from predominantly prostate, colorectal, breast, and lung cancer.

YouTube, TikTok Videos Don’t Provide Quality Information on Prostate Cancer Screening

None of the YouTube or TikTok videos analyzed contained both high-quality and accurate information on prostate cancer screening.

Lung Cancer Among Never-Smokers Common in Women and Men

Lung cancer among never-smokers is the 11th most common cancer among men and the 8th most common among women, a study suggests.

Adcetris Approved for Pediatric Patients With High-Risk Classical Hodgkin Lymphoma

The approval was based on data from the open-label phase 3 AHOD1331 trial.

Libtayo Plus Chemotherapy Approved as First-Line Treatment for Advanced NSCLC

Findings showed that treatment with cemiplimab-rwlc plus platinum-based chemotherapy demonstrated a statistically significant improvement in overall survival.

Assisting Survivors Through Grief After the Loss of a Co-Parent to Cancer

A qualitative study sought to investigate the challenges faced by a surviving parent of dependent children after the cancer-related death of a co-parent.