Oncology

Intervention Reduces Use of Systemic Therapy at End of Life in Cancer Patients

An intervention can increase serious illness conversations and reduce the use of systemic therapy at the end of life in patients with cancer.

Childhood, Adolescent Cancers Linked to Higher Risk of Major Psychiatric Disorders

Compared with the general population, survivors of childhood and adolescent cancers have an increased risk of 6 major psychiatric disorders.

Risks of Sexual Dysfunction Higher for Survivors of Gynecologic Cancers

Researchers sought to determine whether survivors of gynecologic cancers had a higher risk of sexual dysfunction, compared with cancer-free women, and the risk factors for sexual dysfunction.

Deep Learning Model Predicts Lung Cancer Risk Using Single CT Scan

A deep learning model called Sybil can predict a person’s risk of lung cancer using a single low-dose CT scan, a study suggests.

Higher Prostate Cancer Mortality Among Black Men Tied to Social Determinants of Health

Prostate cancer has one of the largest racial disparities in outcomes between Black and White patients, according to investigators.

Immunotherapy Combo Reduces Risk of Cancer Recurrence in Early-Stage Liver Cancer

The IMbrave050 study included 662 patients with HCC at high risk for recurrence after surgical resection or ablation with curative intent.

ACS Report Shows Prostate Cancer on the Rise, Cervical Cancer on the Decline

A report from the American Cancer Society reveals trends in cancer incidence and mortality over time and includes projections for 2023.

Changes in Treatment Prompt Improved Survival for Rectal Cancer

Changes in treatment have led to improvements in overall survival for US patients with rectal cancer, a study suggests.

AstraZeneca Will Withdraw Leukemia Drug Lumoxiti From US Market

Lumoxiti was approved by the FDA in September 2018 for the treatment of adults with relapsed or refractory hairy cell leukemia.

Genitourinary Cancer Incidence and Mortality Varies by Region, Race, and Sex

Incidence and mortality rates for major genitourinary cancers differ according to sex, race/ethnicity, and geographic region.

Monoclonal Antibody Granted Orphan Drug Status for Pancreatic Cancer

ZB131 is a proprietary monoclonal antibody designed to target cancer-specific plectin with high affinity and specificity.

Survey Reveals Confusion About Causes of Cancer, Especially Among Anti-Vaxxers and Conspiracy Theorists

Awareness of factors that cause cancer is especially poor among people who reject vaccines, prefer alternative medicine, or believe conspiracy theories.

Colorectal Cancer Risk Lower Among Patients Invited to Undergo Screening Colonoscopy

Researchers investigated the effects of receiving vs not receiving an invitation to undergo a screening colonoscopy on colorectal cancer risk.

Cigarette Smoking Increases NMIBC Recurrence Risk

Tobacco smoking is the most important modifiable factor associated with bladder cancer risk, according to investigators.

Krazati Approved for KRAS^G12C-Mutated Locally Advanced or Metastatic NSCLC

Krazati is a highly selective and potent oral small molecule inhibitor of KRASG12C.

Tecentriq Approved for Unresectable or Metastatic Alveolar Soft Part Sarcoma

The approval was based on data from a phase 2 study that included 49 patients with unresectable or metastatic ASPS.

Less May Be More When Treating Newly Diagnosed AML

Neither a higher dose of daunorubicin nor a second induction cycle improved outcomes in fit patients with newly diagnosed acute myeloid leukemia.

Bladder Cancer Risk Higher After Radiation vs Surgery for Prostate Cancer

Radiation therapy for prostate cancer is significantly associated with more than twice the risk for bladder cancer compared with radical prostatectomy, a study found.

Influence of Initial Consultation Visit Type on Cancer Clinical Trial Enrollment

Researchers sought to determine prevalence of telemedicine use for initial consultations and its influence on clinical trial enrollment.

Investigational Therapy Gets Fast Track Status for Glioblastoma Multiforme

In preclinical studies, WP1122 has shown to increase cellular uptake of 2-DG, increase drug half-life, and increase the ability to cross the blood brain barrier.