Patients hospitalized for psychiatric disorders undergoing sustained smoking cessation therapy reported higher abstinence rates at 6 months compared with those receiving usual smoking cessation care, according to the results of a recent study published in JAMA Psychiatry.

Researchers used data from the Helping HAND 3 randomized clinical trial ( Identifier: NCT02204956) to evaluate the differences between sustained smoking cessation therapy and usual care among patients hospitalized for psychiatric disorders 6 months after discharge. Sustained care consisted of 4 main components: inpatient motivational counseling; free transdermal nicotine patches on discharge; an offer of free postdischarge telephone quit line, text-based, and/or web-based smoking cessation counseling, and postdischarge automated interactive voice response calls or text messages. Usual care consisted of brief smoking cessation information, self-help materials and advice from the admitting nurse, and an offer to provide nicotine replacement therapy during hospitalization.

Among the 342 participants included in the analysis, the mean age was 35.8 years, 49.4% were women, and 78.4% of the study population identified as being of White race. Mean number of cigarettes smoked per day before therapy was 16.9. Following therapy initiation, participants in the sustained care group evidenced significantly higher 6-month follow-up point-prevalence abstinence rates than those in the usual care group (8.9% vs 3.5%; P =.01). Additionally, the sustained care group was significantly more likely to report using smoking cessation treatment over the 6 months after discharge compared with participants in the usual care group (74.6% vs 40.5%; P <.001).

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“The findings of this randomized clinical trial support the effectiveness of a brief, multicomponent intervention for promoting the use of smoking cessation medication and counseling treatment and ultimately abstinence following hospital discharge,” the study authors wrote. “These findings, if replicated, provide a scalable approach to achieving sustained smoking cessation in patients with serious mental illness following a psychiatric hospital stay.”

Disclosure: Some study authors declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of authors’ disclosures.


Brown RA, Minami H, Hecht J, et al. Sustained care smoking cessation intervention for individuals hospitalized for psychiatric disorders: the Helping HAND 3 randomized clinical trial.]. JAMA Psychiatry. Published online May 5, 2021. doi:10.1001/jamapsychiatry.2021.0707

This article originally appeared on Pulmonology Advisor