HealthDay News — According to a review and meta-analysis published in the Journal of Gastroenterology and Hepatology, statins are associated with a reduced risk of advanced adenoma, but does not seem to be associated with the risk of colorectal adenoma.

Yoon Suk Jung, from the Kangbuk Samsung Hospital in Seoul, South Korea, and colleagues conducted a systematic review to examine the correlation between statin use and the risk of colorectal adenoma. Data were analyzed from 6 studies with 13,239 patients.

The researchers found that across included studies, the median proportion of patients with any adenoma was 29.7% for those taking statins and 31.2% for those not taking statins. 

Among those taking statins, the median proportion with advanced adenomas was 7.7%, compared with 11.3% in those not taking statins. 


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Statin use was not significantly associated with the risk of any adenoma in meta-analysis (pooled relative risk, 0.901; 95% confidence interval, 0.735 to 1.104); however, statin use was correlated with a reduced risk of advanced adenoma (pooled relative risk, 0.833; 95% confidence interval, 0.750 to 0.925).

“Statin use seems to be associated with a reduced risk of advanced adenoma, but not any adenoma,” the authors write. “Statins may prevent neoplastic progression of adenomas rather than the development of adenomas.”

Reference

Jung YS, et al. “Statin Use And The Risk Of Colorectal Adenoma: A Meta-Analysis”. Journal of Gastroenterology and Hepatology. 2016. 31(11): 1823-1830. doi: 10.1111/jgh.13393

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