HealthDay News — According to a study published in the Journal of Clinical Nursing, implementation of sepsis guidelines improves early assessment, recognition and management of patients presenting to an emergency department with sepsis.

Bernadine Romero, from St George Hospital in Kogarah, Australia, and colleagues assessed the number of patients presenting with sepsis before and after implementation of guidelines in emergency departments to improve patient outcomes. 

They conducted a 12-month pre-post retrospective randomized medical record audit of adult patients diagnosed with sepsis. The researchers found that 86.6 and 100% of the pre- and post-groups received intravenous antibiotics. After implementation of the guidelines there was a statistically significant 230-minute reduction in time to antibiotics.

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The post-implementation group, which included 165 patients, received more urgent triage categories (49.1%), had a 758 minute decrease in the average time to second liter of intravenous fluids and experienced improvement in lactate collection (67.9%); these differences were all statistically significant.

“The findings highlight the impact guidelines can have on clinician decision making and behavior that support best practice and positive patient outcomes,” the authors write. “The sepsis guidelines improved the early assessment, recognition and management of patients presenting with sepsis in one tertiary referral emergency department.”


Romero B, Fry M and Roche M. “The Impact Of Evidence Based Sepsis Guidelines On Emergency Department Clinical Practice: A Pre-Post Medical Record Audit”. Journal of Clinical Nursing. 2017. doi: 10.1111/jocn.13728. [Epub ahead of print]

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