HealthDay News — According to a study published in the American Journal of Obstetrics & Gynecology, probiotics have no effect on vaginal health for pregnant women.

Christian Gille, MD, from the University Children’s Hospital in Tuebingen, Germany, and colleagues conducted a randomized trial in which oral Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 or placebo were administered for 8 weeks. 

Participants included 320 women with less than 12 completed weeks of pregnancy. Vaginal swabs were taken before (290 women) and after (271 women) the intervention.

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The researchers observed a decrease in the proportion of normal vaginal microbiota, from 82.6 to 77.8% in the treatment group and from 79.1 to 74.3% in the placebo group. After the intervention, there were no significant differences across groups (P=.297).

“Oral probiotics may be suitable for implementation in antenatal care, but as administered here, had no effect on vaginal health during mid-gestation,” the authors write. “Other application routes or probiotic preparations may be more effective in supporting vaginal microbiota during pregnancy.”


Gille C, et al. “Effect Of Probiotics On Vaginal Health In Pregnancy. EFFPRO, A Randomized Controlled Trial.” American Journal of Obstetrics and Gynecology. 2016. 215 (5): 608.e1-608.e7. doi: 10.1016/ j.ajog.2016.06.021.

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