High intake of vitamin E may protect against development of chronic kidney disease (CKD), according to a study.

Compared with vitamin E intake in the bottom tertile (5.060 mg/d or less; reference), the top tertile (8.770 mg/d or higher) was significantly associated with 14% lower odds of CKD in a fully adjusted model, Jiyuan Li of The Second Xiangya Hospital of Central South University in Changsha, China, and colleagues reported in Clinical Kidney Journal.

The finding is from a cross-sectional study of US National Health and Nutrition Examination Survey (NHANES) 2009-2016 data. The study included 20,295 participants aged 20 years or older. The study population had an overall 15% prevalence of CKD, defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 or urinary albumin to creatinine ratio greater than 30 mg/g.

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The participants had a mean daily dietary vitamin E intake of 8.43 mg/d, much lower than the recommended level of 15 mg/d for individuals older than 14 years, according to the authors.

Li and colleagues also analyzed the association between vitamin E and CKD risk stratification. Compared with the reference, the top tertile of vitamin E intake was not significantly associated with CKD at moderate risk for progression, but was significantly associated with 49% lower odds of CKD with a very high risk for progression.

The investigators concluded that higher intake of vitamin E is effective at preventing CKD, and even more effective at preventing progression to very high-risk CKD.


Li J, Liu Z, Pu Y, Dai H, Peng F. Association between dietary vitamin E intake and chronic kidney disease events in US adults: a cross-sectional study from NHANES 2009-2016. Clin Kidney J. Published online July 7, 2023. doi:10.1093/ckj/sfad162

This article originally appeared on Renal and Urology News