HealthDay News — According to a study published in The Lancet Respiratory Medicine, high-dose influenza vaccination can reduce risk of respiratory-related hospitalization among nursing home residents aged 65 years and older.

Stefan Gravenstein, MD, of the Warren Alpert Medical School and the School of Public Health at Brown University in Providence, RI, and colleagues analyzed Medicare claims data from 38,256 residents of 823 nursing homes in 38 states during the 2013 to 2014 flu season.

A high-dose flu vaccine was given to residents of 409 of the homes, while residents in the other homes received the standard dose. The researchers found that the hospitalization rates for respiratory illnesses were 3.4% for residents who received the high-dose vaccine and 3.9% for those who received the standard dose (adjusted relative risk 0.873, 95% confidence interval 0.776-0.982, P=.023).

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“In our study, a quarter of the sample was over 90. So we asked if the high-dose vaccine also would work better than regular-dose vaccine in the population we consider least able to respond,” Gravenstein said in a university news release. “This paper says, yes, it can.”

The study was funded by the vaccine’s maker, Sanofi-Pasteur.


Gravenstein S, Davidson HE, Taljaard M, et al. Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial. Lancet Respir Med. 2017. doi. 10.1016/S2213-2600(17)30235-7 [Epub ahead of print]

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