HealthDay News — According to a study published in Scientific Reports, low serum 25-hydroxyvitamin D (25[OH]D) is associated with frequent headaches in middle-aged and older men.

Jyrki Virtanen, PhD, from the University of Eastern Kuopio, Finland, and colleagues examined the correlations between serum 25(OH)D and the risk of frequent headache.

Data were included for 2601 men from the population-based Kuopio Ischemic Heart Disease Risk Factor Study, who were aged 42 to 60 years in 1984 to 1989.

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The researchers found that 9.6% of the men reported frequent headache. After adjustment for age and year and month of blood draw, the average serum 25(OH)D concentration was 38.3 nmol/L and 43.9 nmol/L among those with and without frequent headache, respectively (P for difference <.001).

The odds for frequent headache were significantly increased for those in the lowest versus the highest serum 25(OH)D quartile, after multivariable adjustments (113% higher odds).

“In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men,” the authors write.


Virtanen JK, et al. “Low Serum 25-Hydroxyvitamin D Is Associated With Higher Risk Of Frequent Headache In Middle-Aged And Older Men”. Scientific Reports. 2017;7(39697). doi: 10.1038/srep39697

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