HealthDay News — According to a study published in Head & Neck, core-needle biopsies (CNB) are more effective than repeat fine-needle aspirations (FNA) in order to reduce inconclusive results for thyroid nodules.

Young Jun Choi, MD, from the University of Ulsan in Seoul, South Korea, and colleagues compared the results of CNB (210 patients) and repeat FNA (295 patients) for thyroid nodules that were initially read as atypia/follicular lesion of undetermined significance (AUS/FLUS) on FNA.

The researchers found that CNB demonstrated significantly fewer inconclusive results than repeat FNA for the overall nodules (40.9% versus 63.0%). Significant risk factors for inconclusive results included repeat FNA and group FLUS (odds ratios, 1.92 and 2.08, respectively). CNB had higher diagnostic performance than repeat FNA.

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“CNB is more useful than repeat FNAs for reducing inconclusive results and improving the diagnostic performance of thyroid nodules with initial AUS/FLUS FNA results,” the authors write.


Choi YJ, et al. “Core-Needle Biopsy Versus Repeat Fine-Needle Aspiration For Thyroid Nodules Initially Read As Atypia/Follicular Lesion Of Undetermined Significance”. Head & Neck. 2016. doi: 10.1002/hed.24597. [Epub ahead of print]

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