HealthDay News — According to a study published in the Journal of the American Geriatrics Society, high-dose vitamin D3 supplementation is associated with reduced incidence of acute respiratory infection (ARI), but increased incidence of falls in long-term care facility residents.

Adit Ginde, MD, MPH, from the University of Colorado in Aurora, and colleagues conducted a randomized controlled trial among 107 long-term care residents aged 60 years and older. 

Participants were randomized to either a high-dose group that received monthly supplement of 100,000 IU vitamin D3 (55 participants) or a standard-dose group that received a monthly placebo or monthly supplement of 12,000 IU vitamin D3 for those taking 400 to 1,000 IU or <400 IU/day, respectively, as part of usual care (52 participants).

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The researchers found that the high-dose and standard-dose groups had 0.67 and 1.11 ARIs per person-year (incidence rate ratio, 0.60; P=.02). 

The high-dose group had more falls (1.47 versus 0.63 per person-year; incidence rate ratio, 2.33; P<.001). Fractures were uncommon in both groups (0.10 versus 0.19 per person-year in the high-dose and standard-dose groups, respectively; P=.31). Neither group experienced hypercalcemia or kidney stones.

“Monthly high-dose vitamin D3 supplementation reduced the incidence of ARI in older long-term care residents, but was associated with a higher rate of falls without an increase in fractures,” the authors write.


Ginde AA, et al. “High-Dose Monthly Vitamin D For Prevention Of Acute Respiratory Infection In Older Long-Term Care Residents: A Randomized Clinical Trial”. Journal of the American Geriatrics Society. 2016. doi: 10.1111/jgs.14679. [Epub ahead of print]

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