Medicine

Various Factors Affect the Pancreatic Microbiome Following Pancreatic Surgery

Researchers examined the relationship between the pancreatic microbiome and patient characteristics as well as the duodenal microbiome.

Gepirone Under Review for Major Depressive Disorder

Exxua (previously named Travivo) is a novel oral serotonin 1A receptor agonist.

Picking the Best Place to Practice Medicine

Annual pay, growth potential, cost of living are among the important considerations.

IV Ketamine in Treatment-Resistant Bipolar Depression Shows Real-World Efficacy

Researchers sought to characterize real-world efficacy of repeated ketamine infusions for treatment-resistant bipolar depression assessing symptoms of depression, anxiety, suicidality, and functioning.

Aducanumab, Lecanemab for Early AD: The Clinical Trials That Led to FDA Approval

These are the clinical trials that led to the FDA’s approval of aducanumab and lecanemab for early AD, plus, the concerns that loom.

Early DMT Initiation in MS Tied to Favorable Patient-Reported Outcomes

Researchers sought to explore the relationship between the initiation of MS treatment and patient-reported symptoms and health-related quality of life.

Antibiotic Prophylaxis Does Not Prevent Hospital-Acquired Infection in Patients With Cirrhosis

Researchers evaluate whether antibiotic use in patients with decompensated cirrhosis and without infection prevented hospital-acquired infection.

Palpitations, Fatigue, Angina More Likely After COVID-19 vs Other Viral Infections

Researchers conducted a study to assess the long-term effects of COVID-19 infection in comparison with other common respiratory viral infections.

Obeticholic Acid Under Review for Pre-Cirrhotic Liver Fibrosis Due to NASH

The NDA is supported by two 2 positive interim analyses from the phase 3 REGENERATE trial that included patients with biopsy-proven stage 2 or 3 liver fibrosis due to NASH.

Revised Policy Set to Improve Kidney Transplant Waitlist Time for Black Candidates

The OPTN policy revision may increase some Black kidney candidates’ total waiting time, which is a major factor in their transplant priority for organ offers.

Lack of Efficacy Ends Trial Evaluating Janssen’s HIV Vaccine Candidate

The decision to discontinue the study was made based on an analysis from an independent data and safety monitoring board.

Moderna’s mRNA Vaccine Candidate Prevents RSV-Associated Disease in Older Adults

Results showed vaccine efficacy of 83.7% against RSV-LRTD, defined by 2 or more symptoms.

Rykindo Approved for Schizophrenia, Bipolar Disorder

The approval was based on data from adequate and well-controlled studies with risperidone long-acting injection (intramuscular).

Cognitive Behavioral Therapy Efficacious in Autism Spectrum Disorder Across Ages

Investigators sought to evaluate the effectiveness of psychotherapy for comorbid symptoms of anxiety, depression, and OCD among individuals with ASD.

Life Stressors Exacerbate Long COVID Symptoms in Patients Following Hospitalization

In a prospective, longitudinal study, researchers assessed the effect of demographics, pre-COVID-19 comorbidities, index COVID-19 hospitalization metrics, and life stressors on 6- and 12-month outcome metrics in adult patients post-COVID-19 hospitalization.

Complicated Appendicitis More Likely Among Patients With Psychiatric Disorders

Patients with acute appendicitis between 2000 and 2020 were evaluated for complications on the basis of having a mental health diagnosis.

Poor Oral Health Associated With Hospitalization Risk in Cirrhosis

Researchers evaluated oral health as a determinant of 3-month hospitalizations in compensated or decompensated outpatients with cirrhosis.

COVID-19 Update: Long COVID Rehab, Post-mRNA Vaccine Myocarditis, and Home Test-to-Treat Program

Recent COVID-19 updates include a successful pacing program for people with long COVID symptoms, a blood marker for post-vaccine myocarditis, and the first home test-to-treat program.

2022 EULAR Recommendations for Prophylaxis of Infections in Patients With Rheumatic Diseases

The EULAR issued recommendations for the screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases.

Brexpiprazole Gets Priority Review for Agitation With Alzheimer Dementia

The sNDA is supported by data from two phase 3 studies that evaluated the efficacy and safety of brexpiprazole in patients with agitation associated with Alzheimer dementia.